Selank 10mg Research Peptide: Comprehensive Product Guide

Selank 10mg Research Peptides, Selank is a synthetic heptapeptide with documented anxiolytic and nootropic properties, developed as an analog of the immunomodulatory peptide tuftsin.

Research has focused on its potential for modulating GABAergic transmission, supporting cognitive function, and regulating immune responses.

This guide provides researchers with comprehensive product specifications, mechanism of action details, and practical handling information for Selank 10mg research peptide.

What Is Selank?

Selank (also known as TP-7 or Selanc) is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro.

It was originally developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin, a natural immunomodulatory tetrapeptide.

Unlike conventional anxiolytics such as benzodiazepines, Selank has demonstrated anti-anxiety effects without sedation, cognitive impairment, or dependence issues in research models.

Key Product Identifiers

Mechanism of Action

Selank’s research profile involves modulation of multiple neurotransmitter and immune pathways:

1. GABAergic Modulation

Selank acts as a positive allosteric modulator of GABA receptors, enhancing inhibitory neurotransmission. Research has shown that Selank affects GABA binding in a concentration-dependent manner and may interact with benzodiazepine binding sites, though its binding location is distinct.

This mechanism contributes to its anxiolytic properties without the sedative effects associated with traditional benzodiazepines.

2. Enkephalinase Inhibition

Selank inhibits enzymes that degrade enkephalins, prolonging the activity of endogenous opioid peptides. This contributes to its mood-stabilizing and stress-protective effects.

3. Neurotrophic Support

Research indicates Selank promotes Brain-Derived Neurotrophic Factor (BDNF) expression, supporting neuronal resilience, synaptic plasticity, and cognitive function.

4. Monoamine Modulation

Selank influences serotonin metabolism and may affect serotonergic and noradrenergic brain system activity, contributing to its effects on mood and cognitive function.

5. Immunomodulation

As a tuftsin analog, Selank modulates immune responses, including regulation of cytokine balance and expression of inflammation-related genes.

6. Glutamatergic Interaction

Recent research suggests Selank may affect the glycine co-agonist site of NMDA receptors, indicating potential interactions with glutamatergic signaling.

10mg Product Specifications

Standard Product Content

Research-grade Selank is typically supplied as a lyophilized (freeze-dried) powder in vials containing 10mg of the peptide.

Reconstitution Information

For a 10mg vial, standard reconstitution protocol:

Alternative Reconstitution Volumes:

Preparation Table (10mg Vial)

Important: As with all lyophilized peptides, refrigeration is required to maintain stability once reconstituted. Never shake the vial—only gently invert to mix.

How Many Doses in a 10mg Vial?

A 10mg vial provides enough peptide for multiple research applications depending on experimental design:

Preclinical studies have utilized Selank at doses including 0.01 mg/kg (in mouse models) and 100 µg/kg (for gene expression studies).

Research Applications

1. Anxiety and Stress Research

Selank’s most documented research application is in anxiety models:

• Positive allosteric modulation of GABA receptors with minimal sedation

• Stress response reduction in rat models, decreasing affective responses and erroneous escape attempts

• Increased exploratory behavior in rodent models

2. Cognitive Enhancement

• Learning and memory improvement in research models

• Increased sensory attention and mental clarity

• BDNF upregulation supporting neuroplasticity

3. Neuroprotection

• Anti-inflammatory effects via cytokine regulation

• Antioxidant properties protecting neuronal cells

• NMDA receptor modulation potentially relevant to excitotoxicity research

4. Immunomodulation

As a tuftsin analog, Selank is studied for:

• Cytokine balance regulation

• Expression of inflammation-related genes (e.g., Il2rg, Xcr1)

• Immune cell function modulation

5. Addiction Research

Preliminary research suggests Selank may affect dopamine system function, with studies showing it decreases apomorphine-induced verticalization in mice.

Variations and Analogues

Selank Acetate (Diacetate)

The acetate salt form is commonly supplied in research, with CAS 2703745-90-6 and molecular weight 811.9 g/mol. Diacetate versions (CAS not specified in results) may also be available with molecular weight ~871.98 g/mol.

N-Acetyl Selank

A modified version with an acetyl group at the N-terminus has been developed to potentially enhance metabolic stability and alter receptor binding kinetics. The acetylation is believed to reduce susceptibility to exopeptidase cleavage and may confer extended half-life in research models.

Handling and Storage Guidelines

Stability Summary

Best Practices

• Store powder sealed, away from moisture and light

• Allow vial to reach room temperature before reconstitution

• Add diluent slowly to the vial

• Do not shake — gently swirl or invert to dissolve

• Aliquot reconstituted solution to avoid repeated freeze-thaw cycles

• Always use sterile technique and bacteriostatic water for injection studies

Product Availability

The 10mg vial size is a commonly available format for research purposes:

Note: Prices vary significantly between vendors and are subject to change. These figures are for reference only.

Quality Considerations

Specifications to Verify